THE S100A4 TRANSCRIPTIONAL INHIBITOR NICLOSAMIDE REDUCES PRO-INFLAMMATORY AND MIGRATORY PHENOTYPES OF MICROGLIA: IMPLICATIONS FOR AMYOTROPHIC LATERAL SCLEROSIS

S100A4, belonging to a large multifunctional S100 protein Black Seed family, is a Ca2+-binding protein with a significant role in stimulating the motility of cancer and immune cells, as well as in promoting pro-inflammatory properties in different cell types.In the CNS, there is limited information concerning S100A4 presence and function.In this st

In deze bijdrage ga ik allereerst in op regelingen in de nieuwe Wet inkomstenbelasting 2001 (Wet IB 2001) die mogelijk discriminatoir zijn.Vervolgens bespreek ik de methode van toetsing van wetgeving aan het gelijkheidsbeginsel.Daarna komen twee recente Leather arresten (24 januari 2001, BNB 2001/291 en BNB 2001/292) aan bod waarin Penis Sleeves de

The productive endowment based on its definition and concept, contains any provisions on the economy, because by doing productive endowment means transferring the wealth from the effort of consumption towards production and investment in a productive capital which can produce something that can be consumed in next times, either by individuals and g

Acrylamide (AA) and 5-hydroxymethylfurfural (HMF) are by-products of the Maillard reaction that occur during the frying Scooters process.These substances are toxic and pose a potential health risk because they are consumed in high amounts in Western diets.We investigate using plant extracts, including cinnamon, clove, curry leaf, mint, and turmeric